Rapamycin reduces CCR 5 density levels on CD 4 T cells and this effect 4 results in potentiation of Enfuvirtide ( T - 20 ) against R 5 HIV - 1 in vitro
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چکیده
14 15 16 17 18 19 Correspondent footnote: 20 Robert R. Redfield 21 Institute of Human Virology 22 725 W.Lombard St., 23 Baltimore, MD 21201 24 25 Phone: 410-7064613 26 Fax: 410-7064619 27 Email: [email protected] 28 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01602-06 AAC Accepts, published online ahead of print on 7 May 2007
منابع مشابه
Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency virus type 1 in vitro.
The CCR5 chemokine receptor plays a pivotal role in human immunodeficiency virus type 1 (HIV-1) infection. Several studies have suggested that CCR5 density levels in individuals are rate limiting for infection. In addition, CCR5 density levels influence the antiviral activity of the HIV-1 fusion inhibitor enfuvirtide (T-20) against R5 strains. In the present study we demonstrate that rapamycin ...
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تاریخ انتشار 2007